Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMonoamine oxidase B (MAO-B)
LigandBDBM50060898
Substrate/Competitorn/a
Meas. Tech.MAO Inhibition Assay
IC50 8.6e+2± 241 nM
Citation Mostert, SPetzer, APetzer, JP Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase. Chem Biol Drug Des87:737-46 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monoamine oxidase B (MAO-B)
Name:Monoamine oxidase B (MAO-B)
Synonyms:n/a
Type:Protein
Mol. Mass.:58780.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDHVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIQSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50060898
NameBDBM50060898
Synonyms:5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-1,4-dihydronaphthalene-1,4-dione (7a) | 5,8-dihydroxy-1,4-naphthoquinone | CHEMBL274056 | naphthazalin
TypeSmall organic molecule
Emp. Form.C10H6O4
Mol. Mass.190.1522
SMILESOc1ccc(O)c2C(=O)C=CC(=O)c12 |c:9|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a