Target
Apoptosis regulator Bcl-2
Ligand
BDBM178844
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki
0.023±n/a nM
Citation
 Bruncko, MDing, HDoherty, GAElmore, SWHasvold, LHexamer, LAKunzer, ARMantei, RAMcClellan, WJPark, CHPark, CPetros, AMSong, XSouers, AJSullivan, GMTao, ZWang, GTWang, LWang, XWendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent  US9125913 Publication Date 9/8/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
BCL2_MOUSE | Bcl-2 | Bcl2
Type:
Protein
Mol. Mass.:
26409.44
Organism:
Mus musculus (Mouse)
Description:
P10417
Residue:
236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM178844
Synonyms:
US9125913, 416
Type:
Small organic molecule
Emp. Form.:
C44H47ClF2N6O6S
Mol. Mass.:
861.395
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(OCC4(F)CCOCC4)c(F)c3)c(Oc3cccc4[nH]ncc34)c2)=C(C1)c1ccc(Cl)cc1 |c:56|
Structure:
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