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TargetApoptosis regulator Bcl-2
LigandBDBM178880
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki<0.010±n/a nM
Citation Bruncko, MDing, HDoherty, GAElmore, SWHasvold, LHexamer, LAKunzer, ARMantei, RAMcClellan, WJPark, CHPark, CPetros, AMSong, XSouers, AJSullivan, GMTao, ZWang, GTWang, LWang, XWendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:n/a
Type:Protein
Mol. Mass.:26409.44
Organism:Mus musculus (Mouse)
Description:P10417
Residue:236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM178880
NameBDBM178880
Synonyms:US9125913, 452
TypeSmall organic molecule
Emp. Form.C49H57ClN8O7S
Mol. Mass.937.544
SMILESCC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCC(CC4)N4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cccc4[nH]cnc34)c2)=C(C1)c1ccc(Cl)cc1 |c:63,(16.76,-3.2,;15.22,-3.25,;16.04,-1.95,;13.89,-2.48,;12.56,-3.25,;12.56,-4.79,;11.22,-5.56,;9.89,-4.79,;9.89,-3.25,;8.56,-2.48,;7.22,-3.25,;7.22,-4.79,;8.56,-5.56,;5.89,-2.48,;5.89,-.94,;4.55,-.17,;3.22,-.94,;1.89,-.17,;.55,-.94,;1.89,1.37,;.55,2.14,;1.32,3.47,;-.22,.8,;-.78,2.91,;-2.11,2.14,;-3.45,2.91,;-3.45,4.45,;-4.78,5.22,;-6.12,4.45,;-6.12,2.91,;-7.45,2.14,;-8.78,2.91,;-8.78,4.45,;-7.45,5.22,;-10.12,2.14,;-10.12,.6,;-11.45,-.17,;-12.78,.6,;-12.78,2.14,;-11.45,2.91,;-2.11,5.22,;-.78,4.45,;-2.11,6.76,;-.78,7.53,;-3.45,7.53,;3.22,-2.48,;1.89,-3.25,;1.89,-4.79,;3.22,-5.56,;3.22,-7.1,;1.89,-7.87,;.55,-7.1,;-.91,-7.58,;-1.82,-6.33,;-.91,-5.09,;.55,-5.56,;4.55,-3.25,;13.89,-5.56,;15.22,-4.79,;13.89,-7.1,;15.22,-7.87,;15.22,-9.41,;13.89,-10.18,;13.89,-11.72,;12.56,-9.41,;12.56,-7.87,)|
Structure
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