Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM179375
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Binding Assay (FPBA)
Temperature
298.15±n/a K
IC50
250±n/a nM
Comments
extracted
Citation
 Endres, GWLee, PHOlson, KLKramer, JBCiske, FLBarrett, SD Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases US Patent  US9126973 Publication Date 9/8/2015 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM179375
Synonyms:
US9126973, 1
Type:
Small organic molecule
Emp. Form.:
C19H14N4
Mol. Mass.:
298.3413
SMILES:
c1nc([nH]c1-c1cnc(nc1)-c1ccccc1)-c1ccccc1
Structure:
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