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Target
D(3) dopamine receptor
Ligand
BDBM180726
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
3.099±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180726
Synonyms:
US8829029, 26
Type:
Small organic molecule
Emp. Form.:
C24H34FN3O3
Mol. Mass.:
431.5435
SMILES:
COCCC(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2noc3ccc(F)cc23)CC1 |r,wU:7.6,wD:10.10,(5.82,1.49,;6.91,.4,;6.52,-1.09,;7.6,-2.18,;7.21,-3.67,;8.29,-4.75,;5.72,-4.06,;4.63,-2.98,;3.14,-3.37,;2.05,-2.29,;2.45,-.8,;1.36,.29,;-.13,-.11,;-1.21,.98,;-2.7,.58,;-3.79,1.67,;-3.39,3.16,;-1.9,3.56,;-.82,2.47,;-4.88,3.56,;-5.85,4.75,;-7.29,4.2,;-7.21,2.67,;-8.29,1.58,;-7.9,.09,;-6.41,-.31,;-6.01,-1.8,;-5.32,.78,;-5.72,2.27,;3.94,-.4,;5.03,-1.49,)|
Structure:
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