Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM152759
Substrate
n/a
Meas. Tech.
Biological Enzymatic Assay
pH
7.4±n/a
IC50
<50±n/a nM
Comments
extracted
Citation
 Vath, JE; Zahler, R Fumagillol heterocyclic compounds and methods of making and using same US Patent  US9682965 Publication Date 6/20/2017 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM152759
Synonyms:
US10023561, Example 123 | US9682965, 123
Type:
Small organic molecule
Emp. Form.:
C23H38N2O5
Mol. Mass.:
422.5582
SMILES:
[#6]-[#6]-[#7]-[#6]-[#6@H]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Structure:
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