Target
Macrophage colony-stimulating factor 1 receptor [538-972]
Ligand
BDBM181037
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
8±n/a nM
Comments
extracted
Citation
 Flynn, DLKaufman, MDSamarakoon, TCaldwell, TMVogeti, LAhn, YPatt, WCYates, KM Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities US Patent  US9133183 Publication Date 9/15/2015 
Target
Name:
Macrophage colony-stimulating factor 1 receptor [538-972]
Synonyms:
CSF1R | CSF1R_HUMAN | FMS | Proto-oncogene c-Fms | cFMS
Type:
Other Protein Type
Mol. Mass.:
48843.65
Organism:
Homo sapiens (Human)
Description:
Recombinant protein contains the full-length FMS cytoplasmic domain (FMS538-972.6His).
Residue:
435
Sequence:
YKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM181037
Synonyms:
US9133183, Example 42
Type:
Small organic molecule
Emp. Form.:
C21H23N7O3
Mol. Mass.:
421.4524
SMILES:
CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O
Structure:
Search PDB for entries with ligand similarity: