Reaction Details Report a problem with these data
Target
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Ligand
BDBM181109
Substrate
BDBM181110
Meas. Tech.
PEPCK Assay (OAA to PEP-allosteric)
Temperature
298.15±0 K
Ki
1.21e+5± 3.5e+4 nM
Citation
 Balan, MD; Mcleod, MJ; Lotosky, WR; Ghaly, M; Holyoak, T Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry 54:5878-87 (2015) [PubMed]  Article 
Target
Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Synonyms:
Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) | PCKGC_RAT | PEPCK-C | Pck1 | Phosphoenolpyruvate carboxykinase (PEPCK) | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Phosphoenolpyruvate carboxylase
Type:
Protein
Mol. Mass.:
69414.48
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
622
Sequence:
MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM
  
Inhibitor
Name:
BDBM181109
Synonyms:
3-Mercaptopicolinic acid (MPA)
Type:
Small organic molecule
Emp. Form.:
C6H5NO2S
Mol. Mass.:
155.174
SMILES:
OC(=O)c1ncccc1S
Structure:
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Substrate
Name:
BDBM181110
Synonyms:
GTP
Type:
Small organic molecule
Emp. Form.:
C10H16N5O14P3
Mol. Mass.:
523.1804
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Structure:
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