Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM182737
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
IC50
99±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R Selective HDAC1 and HDAC2 inhibitors US Patent  US9145412 Publication Date 9/29/2015 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM182737
Synonyms:
US9145412, Table 1, Compound 3
Type:
Small organic molecule
Emp. Form.:
C27H27N5OS
Mol. Mass.:
469.601
SMILES:
Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1cccs1
Structure:
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