Reaction Details Report a problem with these data
Target
Coagulation factor IX
Ligand
BDBM183022
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
76±n/a nM
Citation
 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application US Patent  US9150544 Publication Date 10/6/2015 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM183022
Synonyms:
US9150544, 56
Type:
Small organic molecule
Emp. Form.:
C24H23F5N6O6S2
Mol. Mass.:
650.598
SMILES:
Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(OC(F)(F)F)cc12 |r|
Structure:
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