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TargetRibosomal protein S6 kinase alpha 2
LigandBDBM184220
Substrate/Competitorn/a
Meas. Tech.Kinase Glo Plus Assay
pH7.5±n/a
IC50 0.64±n/a nM
Commentsextracted
Citation Boyer, SJGao, DAGuo, XKirrane, Jr., TMSarko, CRSnow, RJSoleymanzadeh, FZhang, Y Heterocyclic compounds containing an indole core US Patent US9150577 Publication Date 10/6/2015
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase alpha 2
Name:Ribosomal protein S6 kinase alpha 2
Synonyms:90 kDa ribosomal protein S6 kinase 2 | 90 kDa ribosomal protein S6 kinase 2 (RSK2) | MAP kinase-activated protein kinase 1c | MAPKAPK1C | RPS6KA2(Kin.Dom.1 - N-terminal) | Ribosomal S6 Kinase 3 (RSK-3) | Ribosomal protein S6 kinase alpha-2 | p90-RSK 2 | pp90RSK3
Type:Serine/threonine-protein kinase
Mol. Mass.:83259.46
Organism:Homo sapiens (Human)
Description:n/a
Residue:733
Sequence:
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
QRRGMKRLTSTRL
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  Blast E-value cutoff:
BDBM184220
NameBDBM184220
Synonyms:US9150577, 79
TypeSmall organic molecule
Emp. Form.C23H23N5O2
Mol. Mass.401.461
SMILESCCn1c(NC(=O)c2ccc3cc4C(=O)N[C@H](C)[C@H](C)n4c3c2)nc2ccccc12 |r|
Structure
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n/a