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Target
Insulin receptor [964-1370]
Ligand
BDBM184529
Substrate
n/a
Meas. Tech.
DELFIA Assay
pH
7.4±n/a
IC50
0.66±n/a nM
Comments
extracted
Citation
 Treu, M 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors US Patent  US9150578 Publication Date 10/6/2015 
Target
Name:
Insulin receptor [964-1370]
Synonyms:
INSR | INSR_HUMAN | Insulin-like growth factor 1 receptor (aa 964-1370)
Type:
n/a
Mol. Mass.:
46101.87
Organism:
Homo sapiens (Human)
Description:
P06213[964-1370]
Residue:
407
Sequence:
FVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKN
  
Inhibitor
Name:
BDBM184529
Synonyms:
US9150578, I-158
Type:
Small organic molecule
Emp. Form.:
C31H32N8O2
Mol. Mass.:
548.6382
SMILES:
CCCNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: