Reaction Details Report a problem with these data
Target
Insulin receptor [964-1370]
Ligand
BDBM184534
Substrate
n/a
Meas. Tech.
DELFIA Assay
pH
7.4±n/a
IC50
0.23±n/a nM
Comments
extracted
Citation
 Treu, M 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors US Patent  US9150578 Publication Date 10/6/2015 
Target
Name:
Insulin receptor [964-1370]
Synonyms:
INSR | INSR_HUMAN | Insulin-like growth factor 1 receptor (aa 964-1370)
Type:
n/a
Mol. Mass.:
46101.87
Organism:
Homo sapiens (Human)
Description:
P06213[964-1370]
Residue:
407
Sequence:
FVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKN
  
Inhibitor
Name:
BDBM184534
Synonyms:
US9150578, I-163
Type:
Small organic molecule
Emp. Form.:
C35H39N9O3
Mol. Mass.:
633.7427
SMILES:
CO[C@@H]1CN(C)CC[C@H]1NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1 |r|
Structure:
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