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Target
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)
Ligand
BDBM86806
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
0.26±n/a nM
Citation
 Carroll, FI; Ondachi, PW; Navarro, HA; Damaj, MI; Woods, JH; Jutkiewicz, EM Nicotinic receptor compounds US Patent  US9150581 Publication Date 10/6/2015 
Target
Name:
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)
Synonyms:
ACHA4_RAT | Acra4 | Chrna4 | Neuronal acetylcholine receptor subunit alpha 4 subtype | Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2) | Neuronal acetylcholine receptor subunit alpha-4 beta 2
Type:
Enzyme
Mol. Mass.:
70323.63
Organism:
Rattus norvegicus (Rat)
Description:
P09483-2
Residue:
631
Sequence:
MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
  
Inhibitor
Name:
BDBM86806
Synonyms:
CAS_45263762 | NSC_45263762 | US9150581, RTI-7527-(-)-47 | rac-2-(6-fluoro-5-phenylpyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane hydrochloride
Type:
Small organic molecule
Emp. Form.:
C17H17FN2
Mol. Mass.:
268.3287
SMILES:
Fc1ncc(cc1-c1ccccc1)C1CC2CCC1N2 |TLB:4:13:16.17:19|
Structure:
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