Reaction Details
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Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM184964
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2±n/a nM
Comments
extracted
Citation
Brand, S; Wyatt, P; Thompson, S; Smith, V; Bayliss, T; Harrison, J; Norcross, N; Cleghorn, L; Gilbert, I; Brenk, R N-myristoyl transferase inhibitors US Patent US9156811 Publication Date 10/13/2015 More Info.:
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
N-myristoyltransferase (NMT1)
Type:
Protein
Mol. Mass.:
50529.16
Organism:
Trypanosoma brucei
Description:
Q388H8
Residue:
446
Sequence:
MTDKAFTEHQFWSTQPVRQPGAPDADKVGFIMESSLDAVPAEPYSLPSTFEWWSPDVANPEDLRGVHELLRDNYVEDSESMFRFNYSEEFLRWALMPPGYHQSWHVGVRLKSNKSVLGFVAGVPITMRLGTPKMVLEKREHGEDGGEEVINDYLEPQTICEINFLCVHKKLRQRRLGPILIKEVTRRVNLMNIWHAVYTSGTLLPTPFAKGHYFHRSLNSQKLVDVKFSGIPPHYKRFQNPVAVMERLYRLPDKTKTRGLRLMEPADVPQVTQLLLKRLASFDVAPVFNEEEVAHYFLPREGVVFSYVVESPVGPGKDEENAGKASKGTPTGTKCVTGGCEKVITDFFSFYSLPSTIIGNSNHSLLKVAYVYYTAATSVSITQLVNDLLIIVKLNGFDVCNVVDIYDNGTYLKELKFSPGDGNLYYYFYNWSYPSIPANEVGLVMV
Inhibitor
Name:
BDBM184964
Synonyms:
US9156811, DDD88557
Type:
Small organic molecule
Emp. Form.:
C21H30Cl2N4O2S
Mol. Mass.:
473.46
SMILES:
CN1CCC(CCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)Nc2c(C)nn(C)c2C)CC1
Structure:
