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Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM185061
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
6±n/a nM
Comments
extracted
Citation
 Brand, S; Wyatt, P; Thompson, S; Smith, V; Bayliss, T; Harrison, J; Norcross, N; Cleghorn, L; Gilbert, I; Brenk, R N-myristoyl transferase inhibitors US Patent  US9156811 Publication Date 10/13/2015 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM185061
Synonyms:
US9156811, DDD100144
Type:
Small organic molecule
Emp. Form.:
C23H32Cl2F2N4O2S
Mol. Mass.:
537.494
SMILES:
CN1CCC(CCCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)N(C(F)F)c2c(C)nn(C)c2C)CC1
Structure:
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