Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM185107
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2±n/a nM
Comments
extracted
Citation
 Brand, SWyatt, PThompson, SSmith, VBayliss, THarrison, JNorcross, NCleghorn, LGilbert, IBrenk, R N-myristoyl transferase inhibitors US Patent  US9156811 Publication Date 10/13/2015 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM185107
Synonyms:
US9156811, DDD100868
Type:
Small organic molecule
Emp. Form.:
C26H34N4O2S
Mol. Mass.:
466.639
SMILES:
CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCCN(C)Cc2c1
Structure:
Search PDB for entries with ligand similarity: