Reaction Details
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Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM185058
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3±n/a nM
Comments
extracted
Citation
Brand, S; Wyatt, P; Thompson, S; Smith, V; Bayliss, T; Harrison, J; Norcross, N; Cleghorn, L; Gilbert, I; Brenk, R N-myristoyl transferase inhibitors US Patent US9156811 Publication Date 10/13/2015 More Info.:
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
Glycylpeptide N-tetradecanoyltransferase | N-myristoyltransferase (NMT1)
Type:
Protein
Mol. Mass.:
48514.36
Organism:
Leishmania major
Description:
Q4Q5S8
Residue:
421
Sequence:
MSRNPSNSDAAHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML
Inhibitor
Name:
BDBM185058
Synonyms:
US9156811, DDD100141
Type:
Small organic molecule
Emp. Form.:
C23H32Cl2F2N4O2S
Mol. Mass.:
537.494
SMILES:
Cc1nn(C)c(C)c1N(CC(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Structure:
