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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM185287
Substrate
n/a
Meas. Tech.
Fluorescent Imaging Plate Reader (FLIPR) Assay
Temperature
310.15±n/a K
IC50
8±n/a nM
Comments
extracted
Citation
 Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists US Patent  US9156829 Publication Date 10/13/2015 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM185287
Synonyms:
US10011588, Example 103 | US10689373, Example 103 | US9156829, 103
Type:
Small organic molecule
Emp. Form.:
C20H19F4N7O
Mol. Mass.:
449.4048
SMILES:
CC1(CCCC1NC(=O)c1ncccc1-n1nccn1)Nc1ncc(cc1F)C(F)(F)F
Structure:
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