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TargetCyclin-Dependent Kinase 1 (CDK1)
LigandBDBM5515
Substrate/CompetitorHistone H1
Meas. Tech.Kinase Inhibition Assay
Citation Gibson, AEArris, CEBentley, JBoyle, FTCurtin, NJDavies, TGEndicott, JAGolding, BTGrant, SGriffin, RJJewsbury, PJohnson, LNMesguiche, VNewell, DRNoble, METucker, JAWhitfield, HJ Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem45:3381-93 (2002) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cyclin-Dependent Kinase 1 (CDK1)
Name:Cyclin-Dependent Kinase 1 (CDK1)
Synonyms:CDK1/Cyclin B | p34cdc2/Cyclin B
Type:Protein Complex
Mol. Mass.:n/a
Description:p34cdc2/cyclin B was purified from M-phase starfish oocytes by affinity chromatography.
Components:This complex has 2 components.
Component 1
Name:CDK1
Synonyms:Cell division control protein 2 (cdc2) | P34 protein kinase
Type:Enzyme Subunit
Mol. Mass.:358.43
Organism:Marthasterias glacialis (starfish)
Description:n/a
Residue:3
Sequence:
n/a
 
Component 2
Name:Cyclin B
Synonyms:G2/mitotic-specific cyclin-B1
Type:Enzyme Subunit
Mol. Mass.:43790.28
Organism:Marthasterias glacialis (starfish)
Description:n/a
Residue:388
Sequence:
MLNGENVDSRIMGKVATRASSKGVKSTLGTRGALENISNVARNNLQAGAKKELVKAKRGM
TKSKATSSLQSVMGLNVEPMEKAKPQSPEPMDMSEINSALEAFSQNLLEGVEDIDKNDFD
NPQLCSEFVNDIYQYMRKLEREFKVRTDYMTIQEITERMRSILIDWLVQVHLRFHLLQET
LFLTIQILDRYLEVQPVSKNKLQLVGVTSMLIAAKYEEMYPPEIGDFVYITDNAYTKAQI
RSMECNILRRLDFSLGKPLCIHFLRRNSKAGGVDGQKHTMAKYLMELTLPEYAFVPYDPS
EIAAAALCLSSKILEPDMEWGTTLVHYSAYSEDHLMPIVQKMALVLKNAPTAKFQAVRKK
YSSAKFMNVSTISALTSSTVMDLADQMC
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  Blast E-value cutoff:
BDBM5515
NameBDBM5515
Synonyms:(5R)-5-{[(2-amino-9H-purin-6-yl)oxy]methyl}pyrrolidin-2-one | 2-Amino-6-[(R)-pyrrolidinon-5 -yl]methoxypurine | O6-Substituted Guanine Deriv. 56
TypeSmall organic molecule
Emp. Form.C10H12N6O2
Mol. Mass.248.2413
SMILESNc1nc(OC[C@H]2CCC(=O)N2)c2[nH]cnc2n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Histone H1
Name:Histone H1
Synonyms:Sigma Type IIIS
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:12.5 uM ATP as co-substrate.
Residue:3
Sequence:
n/a