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TargetCyclin-Dependent Kinase 2 (CDK2)
LigandBDBM5515
Substrate/CompetitorHistone H1
Meas. Tech.Kinase Inhibition Assay
Citation Gibson, AEArris, CEBentley, JBoyle, FTCurtin, NJDavies, TGEndicott, JAGolding, BTGrant, SGriffin, RJJewsbury, PJohnson, LNMesguiche, VNewell, DRNoble, METucker, JAWhitfield, HJ Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem45:3381-93 (2002) [PubMed]  Article
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Cyclin-Dependent Kinase 2 (CDK2)
Name:Cyclin-Dependent Kinase 2 (CDK2)
Synonyms:CDK2/cyclin A3 | p33cdk2/cyclin A3
Type:Protein Complex
Mol. Mass.:n/a
Description:Binary complex of CDK2-cyclin A3 was formed by adding cyclin A3 in slight molar excess to the CDK2 subunit and purified by Superdex 75 gel filtration chromatography.
Components:This complex has 2 components.
Component 1
Name:CDK2/Bovine cyclin A
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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Component 2
Name:cyclin A3
Synonyms:n/a
Type:Enzyme Subunit
Mol. Mass.:29930.91
Organism:Homo sapiens (Human)
Description:cyclin A3 is a c-terminal cyclin A fragment encoding residues 171-432.
Residue:261
Sequence:
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHL
AVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSV
IAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNLLNL
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BDBM5515
NameBDBM5515
Synonyms:(5R)-5-{[(2-amino-9H-purin-6-yl)oxy]methyl}pyrrolidin-2-one | 2-Amino-6-[(R)-pyrrolidinon-5 -yl]methoxypurine | O6-Substituted Guanine Deriv. 56
TypeSmall organic molecule
Emp. Form.C10H12N6O2
Mol. Mass.248.2413
SMILESNc1nc(OC[C@H]2CCC(=O)N2)c2[nH]cnc2n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Histone H1
Name:Histone H1
Synonyms:Sigma Type IIIS
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:12.5 uM ATP as co-substrate.
Residue:3
Sequence:
n/a