Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM263597
Substrate
n/a
Meas. Tech.
WNT pathway reporter gene assay
IC50
15.0±n/a nM
Citation
 An, S Compound as WNT signaling inhibitor, composition, and use thereof US Patent  US10087181 Publication Date 10/2/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM263597
Synonyms:
US10087181, Compound 84 | US10285988, Compound 84 | US9713612, 84
Type:
Small organic molecule
Emp. Form.:
C26H27N5O
Mol. Mass.:
425.5255
SMILES:
CC1CN(CCO1)c1cc2ccnc(NCc3ccc(cc3)-c3ccnc(C)c3)c2cn1
Structure:
Search PDB for entries with ligand similarity: