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Target
D(2) dopamine receptor
Ligand
BDBM185697
Substrate
n/a
Meas. Tech.
cAMP GloSensor Assay
pH
7.4±n/a
EC50
0.4±n/a nM
Comments
extracted
Citation
 Jin, J; Roth, B; Frye, S Functionally selective ligands of dopamine D2 receptors US Patent  US9156822 Publication Date 10/13/2015 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM185697
Synonyms:
UNC10108018 | US9156822, 41
Type:
Small organic molecule
Emp. Form.:
C24H30N4O4
Mol. Mass.:
438.5194
SMILES:
O=C1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4OCCOc34)nc2N1
Structure:
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