Reaction Details
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Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM185772
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
>100000±n/a nM
Citation
Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent US9162991 Publication Date 10/20/2015 More Info.:
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
TGM2 | TGM2_CAVCU | Transglutaminases (TGase)
Type:
Enzyme
Mol. Mass.:
77122.36
Organism:
Cavia cutleri (Guinea pig)
Description:
P08587
Residue:
690
Sequence:
MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA
Inhibitor
Name:
BDBM185772
Synonyms:
US9162991, 15d
Type:
Small organic molecule
Emp. Form.:
C16H13N3O2
Mol. Mass.:
279.2933
SMILES:
COc1ccc(\C=C\C(=O)n2nnc3ccccc23)cc1
Structure:
