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Target
Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM185762
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
10700±1100 nM
Citation
 Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent  US9162991 Publication Date 10/20/2015 
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
TGM2 | TGM2_CAVCU | Transglutaminases (TGase)
Type:
Enzyme
Mol. Mass.:
77122.36
Organism:
Cavia cutleri (Guinea pig)
Description:
P08587
Residue:
690
Sequence:
MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA
  
Inhibitor
Name:
BDBM185762
Synonyms:
US9162991, 4h
Type:
Small organic molecule
Emp. Form.:
C18H13N5O5
Mol. Mass.:
379.3263
SMILES:
[O-][N+](=O)c1cccc(Cn2cc(nn2)C(=O)\C=C\c2ccc(cc2)N(=O)=O)c1
Structure:
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