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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM186151
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay
Temperature298.15±n/a K
IC50 0.46±n/a nM
Commentsextracted
Citation Claremon, DATice, CMZhuang, LLeftheris, KYe, YSingh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM186151
NameBDBM186151
Synonyms:US9163012, 68
TypeSmall organic molecule
Emp. Form.C23H27ClN4O4
Mol. Mass.458.938
SMILESNC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)n1c4c(Cl)cccc4[nH]c1=O)C(C3)C2 |r,wU:9.10,16.19,wD:3.2,TLB:6:7:31:4.5.30,6:5:31:7.9.8,THB:9:7:4:31.29.30,9:29:4:7.6.8,10:9:31:4.5.30,(-8.38,-1.67,;-7.04,-2.44,;-7.04,-3.98,;-5.71,-1.67,;-6.54,-3.58,;-5.15,-2.93,;-3.94,-3.6,;-3.05,-1.67,;-4.38,-2.45,;-3.05,-.13,;-1.71,.64,;-.38,-.13,;-.38,-1.67,;.95,.64,;.95,2.18,;2.42,2.65,;3.32,1.41,;2.42,.16,;4.86,1.41,;5.77,.16,;5.45,-1.35,;3.96,-1.75,;6.59,-2.38,;8.06,-1.9,;8.38,-.4,;7.23,.64,;7.23,2.18,;5.77,2.65,;5,3.98,;-4.38,.63,;-5.13,-.53,;-5.71,-.13,)|
Structure
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