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TargetLipoamide Dehydrogenase (Lpd)
LigandBDBM188269
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7±n/a
IC50 2280±110 nM
Commentsextracted
Citation Wong, CWu, Y Compounds and methods for treating tuberculosis infection US Patent US9073941 Publication Date 7/7/2015
More Info.:Get all data from this article,  Assay Method
 
Lipoamide Dehydrogenase (Lpd)
Name:Lipoamide Dehydrogenase (Lpd)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:49231.98
Organism:Mycobacterium tuberculosis
Description:P9WHH9
Residue:464
Sequence:
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVH
IFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANT
LLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAG
AIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
GGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTN
VGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGL
TEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELL
PELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM188269
NameBDBM188269
Synonyms:US9073941, 551
TypeSmall organic molecule
Emp. Form.C20H25N5O4S2
Mol. Mass.463.574
SMILESCOc1ccc2nc(NC(=O)C3CCN(CC3)S(=O)(=O)c3cn(cn3)C(C)C)sc2c1
Structure
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