Reaction Details
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D(4) dopamine receptor
Ligand
BDBM186938
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
2486±n/a nM
Comments
extracted
Citation
Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K Morpholino compounds, uses and methods US Patent US9079895 Publication Date 7/14/2015 More Info.:
Target
Name:
D(4) dopamine receptor
Synonyms:
DRD4_MOUSE | Dopamine D4 receptor | Drd4
Type:
Enzyme
Mol. Mass.:
41498.73
Organism:
Mus musculus (Mouse)
Description:
P51436
Residue:
387
Sequence:
MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
Inhibitor
Name:
BDBM186938
Synonyms:
US9079895, 25r
Type:
Small organic molecule
Emp. Form.:
C22H26N2O4
Mol. Mass.:
382.4528
SMILES:
COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc34)CCO2)c1 |r|
Structure:
