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TargetNicotinamide phosphoribosyltransferase
LigandBDBM186994
Substrate/Competitorn/a
Meas. Tech.Biochemical Inhibition Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1.1±n/a nM
Commentsextracted
Citation Bair, KWBaumeister, TBuckmelter, AJClodfelter, KHHan, BLin, JReynolds, DJSmith, CCWang, ZZheng, X Compounds and compositions for the inhibition of NAMPT US Patent US9169209 Publication Date 10/27/2015
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM186994
NameBDBM186994
Synonyms:US9169209, Table 3, Compound 25
TypeSmall organic molecule
Emp. Form.C23H22N2O4S
Mol. Mass.422.497
SMILESCC(C)Oc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Structure
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