Reaction Details Report a problem with these data
Target
Sepiapterin reductase
Ligand
BDBM187258
Substrate
n/a
Meas. Tech.
LC/MS assay
pH
6.5±n/a
Temperature
310.15±n/a K
IC50
12±n/a nM
Comments
extracted
Citation
 Blagg, J Sepiapterin reductase inhibitors for the treatment of pain US Patent  US9169234 Publication Date 10/27/2015 
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM187258
Synonyms:
US9169234, 23
Type:
Small organic molecule
Emp. Form.:
C14H18N2O3
Mol. Mass.:
262.3043
SMILES:
COCC(=O)NCCc1c(C)[nH]c2ccc(O)cc12
Structure:
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