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Target
Kappa-type opioid receptor
Ligand
BDBM156523
Substrate
n/a
Meas. Tech.
OPRK1 antagonist assay
Temperature
298.15±n/a K
IC50
0.50±n/a nM
Comments
extracted
Citation
 Roberts, E; Guerrero, MA; Urbano, M; Rosen, H Kappa opioid ligands US Patent  US9682966 Publication Date 6/20/2017 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM156523
Synonyms:
US10118915, Compound 309 | US9682966, 309
Type:
Small organic molecule
Emp. Form.:
C24H31N5O2
Mol. Mass.:
421.5352
SMILES:
COC1CN(CCC1NC1CCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1
Structure:
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