Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK [360-635]
Ligand
BDBM188164
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
141.44±n/a nM
Citation
 Hermann, JC; Kuglstatter, A; Lucas, MC; Padilla, F; Wanner, J; Zhang, X Imidazopyridazine compounds US Patent  US9169259 Publication Date 10/27/2015 
Target
Name:
Tyrosine-protein kinase SYK [360-635]
Synonyms:
KSYK_HUMAN | SYK | SYK RPA purified, truncated construct of Spleen Tyrosine Kinase (aa 360-635) | Tyrosine-protein kinase SYK | recombinant human SYK(aa 360-635)
Type:
n/a
Mol. Mass.:
31987.15
Organism:
Homo sapiens (Human)
Description:
Human MetAP2 protein from a culture superatant of insect cells (sf9) infected with MetAP2 recombinant baculovirus
Residue:
276
Sequence:
PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM188164
Synonyms:
US9169259, I-46
Type:
Small organic molecule
Emp. Form.:
C27H32N8O
Mol. Mass.:
484.596
SMILES:
CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)NCCN(C)C)n1
Structure:
Search PDB for entries with ligand similarity: