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Target
Tyrosine-protein kinase SYK [360-635]
Ligand
BDBM188188
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.2±n/a nM
Citation
 Hermann, JC; Kuglstatter, A; Lucas, MC; Padilla, F; Wanner, J; Zhang, X Imidazopyridazine compounds US Patent  US9169259 Publication Date 10/27/2015 
Target
Name:
Tyrosine-protein kinase SYK [360-635]
Synonyms:
KSYK_HUMAN | SYK | SYK RPA purified, truncated construct of Spleen Tyrosine Kinase (aa 360-635) | Tyrosine-protein kinase SYK | recombinant human SYK(aa 360-635)
Type:
n/a
Mol. Mass.:
31987.15
Organism:
Homo sapiens (Human)
Description:
Human MetAP2 protein from a culture superatant of insect cells (sf9) infected with MetAP2 recombinant baculovirus
Residue:
276
Sequence:
PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM188188
Synonyms:
US9169259, I-72
Type:
Small organic molecule
Emp. Form.:
C26H27N7O5
Mol. Mass.:
517.5365
SMILES:
COc1ccc(Nc2cc(nn3ccnc23)N2CCCC(C2)NC(=O)c2ccc(cc2)C(O)=O)nc1OC
Structure:
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