Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM188521
Substrate
n/a
Meas. Tech.
[3H]-2-Deoxy-D-glucose ([3H]-2-DG) Uptake Assay
IC50
4.5e+2±n/a nM
Citation
 Ung, PM; Song, W; Cheng, L; Zhao, X; Hu, H; Chen, L; Schlessinger, A Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening. ACS Chem Biol 11:1908-16 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GLUT-1 | GLUT1 | GTR1_HUMAN | Glucose Transporter 1 (hGLUT1) | Glucose transporter | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1
Type:
Protein
Mol. Mass.:
54091.71
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
492
Sequence:
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
  
Inhibitor
Name:
BDBM188521
Synonyms:
PUG-1
Type:
Small organic molecule
Emp. Form.:
C12H10N4O2
Mol. Mass.:
242.2334
SMILES:
O[C@H](c1nc2nc[nH]c(=O)c2[nH]1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: