Reaction Details Report a problem with these data
Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50438882
Substrate
n/a
Meas. Tech.
Recombinant TDP2 Assay
pH
7.5±n/a
IC50
>1.11e+5±n/a nM
Comments
extracted
Citation
 Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol 11:1925-33 (2016) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)
Type:
Protein
Mol. Mass.:
41027.02
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
370
Sequence:
MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
  
Inhibitor
Name:
BDBM50438882
Synonyms:
10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (5) | CHEMBL471342
Type:
Small organic molecule
Emp. Form.:
C17H11N3O2
Mol. Mass.:
289.2881
SMILES:
O=c1nc2n(-c3ccccc3)c3ccccc3cc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: