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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM288609
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
56.5±n/a nM
Citation
 Yu, S; Yang, F; Chen, L; Yan, J; Zhang, X; Xie, Z; Chen, L; He, M Piperidine derivative and preparation method and pharmaceutical use thereof US Patent  US10087191 Publication Date 10/2/2018 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM288609
Synonyms:
(E)-3-(3,5-difluoro-4-((1R,3S)-2-(2-fluoro-2-methylpropyl)-3-methyl-6-(2-methylthiazol-5-yl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phenyl)acrylic acid | US10087191, Example 12
Type:
Small organic molecule
Emp. Form.:
C27H27F3N2O2S
Mol. Mass.:
500.576
SMILES:
C[C@H]1Cc2cc(ccc2[C@@H](N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F)-c1cnc(C)s1 |r|
Structure:
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