Target
Prostaglandin D2 receptor 2
Ligand
BDBM189154
Substrate
n/a
Meas. Tech.
Radioligand Displacement Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
45.1±n/a nM
Comments
extracted
Citation
 Aissaoui, HBoss, CRichard-Bildstein, SSiegrist, R 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators US Patent  US9169270 Publication Date 10/27/2015 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM189154
Synonyms:
US9169270, 26
Type:
Small organic molecule
Emp. Form.:
C26H24ClN3O5S
Mol. Mass.:
526.004
SMILES:
COc1ccc2[nH]cc(CCC(=O)N3CCc4ncsc4C3c3cc(Cl)ccc3OCC(O)=O)c2c1
Structure:
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