Reaction Details Report a problem with these data
Target
Sonic hedgehog protein
Ligand
BDBM189287
Substrate
n/a
Meas. Tech.
Gli-Luc Assay
Temperature
310.15±n/a K
IC50
<5000±n/a nM
Comments
extracted
Citation
 Guicherit, OM; Rubin, L Mediators of hedgehog signaling pathways, compositions and uses related thereto US Patent  US9173869 Publication Date 11/3/2015 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM189287
Synonyms:
US9173869, 67
Type:
Small organic molecule
Emp. Form.:
C24H18F4N4O2S
Mol. Mass.:
502.484
SMILES:
Cc1c(NC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)cccc1SC(F)(F)F
Structure:
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