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Target
Isoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Ligand
BDBM86642
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
>100000±n/a nM
Citation
 Hoffman, CS; Ceyhan, O Inhibitors of phosphodiesterase 11 (PDE11) US Patent  US9173884 Publication Date 11/3/2015 
Target
Name:
Isoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Synonyms:
PDE2A | PDE2A_HUMAN | Phosphodiesterase 2A (PDE2A2) | cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A2)
Type:
Protein
Mol. Mass.:
105121.70
Organism:
Homo sapiens (Human)
Description:
O00408-3
Residue:
934
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
  
Inhibitor
Name:
BDBM86642
Synonyms:
BC11-38 | US9173884, BC11-38
Type:
Small organic molecule
Emp. Form.:
C15H16N2OS2
Mol. Mass.:
304.43
SMILES:
CCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Structure:
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