Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor [1-198]/[199-335]
Ligand
BDBM189330
Substrate
n/a
Meas. Tech.
Tet-Inducible cAMP Assay
EC50
4±n/a nM
Citation
 Broekema, M; Wu, G; Wacker, DA Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators US Patent  US9174965 Publication Date 11/3/2015 
Target
Name:
Glucose-dependent insulinotropic receptor [1-198]/[199-335]
Synonyms:
Human-mouse GPR119
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glucose-dependent insulinotropic receptor [1-198]
Synonyms:
GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor (GPR119)
Type:
Enzyme
Mol. Mass.:
21505.57
Organism:
Homo sapiens (Human)
Description:
Q8TDV5: The first 198 amino acids of human GPR119
Residue:
198
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQ
  
Component 2
Name:
Glucose-dependent insulinotropic receptor [199-335]
Synonyms:
GP119_MOUSE | Glucose-dependent insulinotropic receptor (GPR119) | Gpr119
Type:
Enzyme
Mol. Mass.:
15641.79
Organism:
Mus musculus (Mouse)
Description:
Q7TQP3: C-terminal 137 amino acids of the mouse receptor GPR119
Residue:
137
Sequence:
IRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM189330
Synonyms:
US9174965, 2
Type:
Small organic molecule
Emp. Form.:
C27H32N6O4
Mol. Mass.:
504.5808
SMILES:
CCCc1cnc(nc1)N1CCC(CC1)Oc1ccn(-c2ccc(N3CCC(O)C3=O)c(C)n2)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: