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TargetCyclin-Dependent Kinase 2 (CDK2)
LigandBDBM5485
Substrate/CompetitorHistone H1
Meas. Tech.Kinase Inhibition Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 17000±2000 nM
Citation Hardcastle, IRArris, CEBentley, JBoyle, FTChen, YCurtin, NJEndicott, JAGibson, AEGolding, BTGriffin, RJJewsbury, PMenyerol, JMesguiche, VNewell, DRNoble, MEPratt, DJWang, LZWhitfield, HJ N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. J Med Chem47:3710-22 (2004) [PubMed]  Article
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Cyclin-Dependent Kinase 2 (CDK2)
Name:Cyclin-Dependent Kinase 2 (CDK2)
Synonyms:CDK2/cyclin A3 | p33cdk2/cyclin A3
Type:Protein Complex
Mol. Mass.:n/a
Description:Binary complex of CDK2-cyclin A3 was formed by adding cyclin A3 in slight molar excess to the CDK2 subunit and purified by Superdex 75 gel filtration chromatography.
Components:This complex has 2 components.
Component 1
Name:CDK2/Bovine cyclin A
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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Component 2
Name:cyclin A3
Synonyms:n/a
Type:Enzyme Subunit
Mol. Mass.:29930.91
Organism:Homo sapiens (Human)
Description:cyclin A3 is a c-terminal cyclin A fragment encoding residues 171-432.
Residue:261
Sequence:
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHL
AVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSV
IAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNLLNL
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BDBM5485
NameBDBM5485
Synonyms:6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269881 | NU2058
TypeSmall organic molecule
Emp. Form.C12H17N5O
Mol. Mass.247.2963
SMILESNc1nc(OCC2CCCCC2)c2[nH]cnc2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Histone H1
Name:Histone H1
Synonyms:Sigma Type IIIS
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:12.5 uM ATP as co-substrate.
Residue:3
Sequence:
n/a