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Target
Kinesin-like protein KIF11 [15-368]
Ligand
BDBM189361
Substrate
n/a
Meas. Tech.
ADP Hunter Plus Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
1.183e+5±n/a nM
Comments
extracted
Citation
 Zhang, W; Zhai, L; Lu, W; Boohaker, RJ; Padmalayam, I; Li, Y Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. Chem Biol Drug Des 88:178-87 (2016) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF11 [15-368]
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Mitotic kinesin Eg5 (Eg5) | TRIP5
Type:
Protein
Mol. Mass.:
39484.97
Organism:
Homo sapiens (Human)
Description:
Eg5 motor domain (15-368aa)
Residue:
354
Sequence:
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK
  
Inhibitor
Name:
BDBM189361
Synonyms:
SRI35564
Type:
Small organic molecule
Emp. Form.:
C13H12N6
Mol. Mass.:
252.2746
SMILES:
Cc1ccc(cc1)C1C(C#N)=C(N)Nc2ncnn12 |t:11|
Structure:
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