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Target
Neutrophil elastase
Ligand
BDBM189908
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
<0.3±n/a nM
Comments
extracted
Citation
 Von Nussbaum, F; Karthaus, D; Anlauf, S; Delbeck, M; Li, VM; Meibom, D; Lustig, K; Schamberger, J 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof US Patent  US9174997 Publication Date 11/3/2015 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM189908
Synonyms:
US9174997, 128
Type:
Small organic molecule
Emp. Form.:
C23H19F3N4O3S
Mol. Mass.:
488.482
SMILES:
CCS(=O)(=O)c1cc(ccc1[C@H]1N(C)C(=O)N(C(C)=C1[N+]#[C-])c1cccc(c1)C(F)(F)F)C#N |r,c:19|
Structure:
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