Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase EZH2 [A677G]
Ligand
BDBM190199
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.5±n/a nM
Citation
 Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent  US9175331 Publication Date 11/3/2015 
Target
Name:
Histone-lysine N-methyltransferase EZH2 [A677G]
Synonyms:
EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6
Type:
Protein
Mol. Mass.:
85381.87
Organism:
Homo sapiens (Human)
Description:
Q15910[A677G]
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDGTRKGNKIRFVNHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM190199
Synonyms:
EPZ008286 | US9175331, 29
Type:
Small organic molecule
Emp. Form.:
C31H42N4O2
Mol. Mass.:
502.6908
SMILES:
CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CC1CC1 |r,wU:3.2,wD:6.9,(-2,5.67,;-3.33,4.9,;-3.33,3.36,;-4.67,2.59,;-4.67,1.05,;-6,.28,;-7.34,1.05,;-7.34,2.59,;-6,3.36,;-8.67,.28,;-10,1.05,;-8.67,-1.26,;-2,2.59,;-2,1.05,;-.67,.28,;.67,1.05,;.67,2.59,;2,3.36,;2,4.9,;3.33,2.59,;4.67,3.36,;6,2.59,;7.34,3.36,;7.34,4.9,;8.67,2.59,;8.67,1.05,;10,.28,;7.34,.28,;6,1.05,;4.67,.28,;-.67,3.36,;-.67,4.9,;-.67,-1.26,;-.67,-2.8,;-.67,-4.34,;-1.44,-5.67,;.1,-5.67,)|
Structure:
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