Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM190656
Substrate
n/a
Meas. Tech.
Steady-State Kinetics
pH
8±n/a
Temperature
298.15±n/a K
Ki
1.6e+4± 5e+3 nM
Comments
extracted
Citation
 Neckles, C; Pschibul, A; Lai, CT; Hirschbeck, M; Kuper, J; Davoodi, S; Zou, J; Liu, N; Pan, P; Shah, S; Daryaee, F; Bommineni, GR; Lai, C; Simmerling, C; Kisker, C; Tonge, PJ Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase. Biochemistry 55:2992-3006 (2016) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP reductase (Wt ypFabV) | FABV_YERPE | fabV
Type:
Protein
Mol. Mass.:
43335.99
Organism:
Yersinia pestis (Enterobacteria)
Description:
n/a
Residue:
399
Sequence:
MIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESVLQPATQSEIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQLTDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPNLIQG
  
Inhibitor
Name:
BDBM190656
Synonyms:
PT424
Type:
Small organic molecule
Emp. Form.:
C18H22N2O3
Mol. Mass.:
314.3789
SMILES:
CCCCCCc1ccn(Cc2ccc(cc2)[N+]([O-])=O)c(=O)c1
Structure:
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