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TargetBeta-secretase 2 (BACE2)
LigandBDBM190699
Substrate/Competitorn/a
Meas. Tech.HTRF FRET Assay
Ki 0.9±n/a nM
Citation Wu, WBurnett, DAStamford, AWCumming, JNAsberom, TBennett, CSasiskumar, TKScott, JD 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use US Patent US9181236 Publication Date 11/10/2015
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 2 (BACE2)
Name:Beta-secretase 2 (BACE2)
Synonyms:ASP1 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | Beta secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:Enzyme
Mol. Mass.:56171.20
Organism:Homo sapiens (human)
Description:n/a
Residue:518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM190699
NameBDBM190699
Synonyms:US9181236, 3
TypeSmall organic molecule
Emp. Form.C19H18F2N4O3S
Mol. Mass.420.433
SMILESC[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a