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Target
G-protein coupled receptor 6
Ligand
BDBM190953
Substrate
n/a
Meas. Tech.
GPR6 In Vitro Assay (A.1)
Temperature
310.15±n/a K
IC50
0.145±n/a nM
Comments
extracted
Citation
 Brown, J; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent  US9181249 Publication Date 11/10/2015 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM190953
Synonyms:
US10077266, Example 66 | US9181249, 66 | US9708313, 66
Type:
Small organic molecule
Emp. Form.:
C23H30FN5O2
Mol. Mass.:
427.515
SMILES:
COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC2CC2)c(F)c1
Structure:
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