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TargetG-protein coupled receptor 6
LigandBDBM190994
Substrate/Competitorn/a
Meas. Tech.GPR6 In Vitro Assay (A.1)
Temperature310.15±n/a K
IC50 0.0249±n/a nM
Commentsextracted
Citation Brown, JHitchcock, SHopkins, MKikuchi, SMonenschein, HReichard, HSchleicher, KSun, HMacklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent US9181249 Publication Date 11/10/2015
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
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  Blast E-value cutoff:
BDBM190994
NameBDBM190994
Synonyms:US10077266, Example 107 | US9181249, 107 | US9708313, 107
TypeSmall organic molecule
Emp. Form.C23H27F4N5O2
Mol. Mass.481.4864
SMILESCC1Cc2nc(NCC(F)F)c(nc2CN1C(C)=O)N1CCC(CC1)Oc1ccc(F)cc1F
Structure
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