Reaction Details Report a problem with these data
Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM288879
Substrate
n/a
Meas. Tech.
TR-FRET PIK3 Assay
pH
7.4±n/a
IC50
400±n/a nM
Comments
extracted
Citation
 Cai, S; Du, Z; Kaplan, J; Loyer-Drew, JA; Naduthambi, D; Phillips, BW; Phillips, G; Van Veldhuizen, J; Watkins, WJ; Yeung, SC Phosphatidylinositol 3-kinase inhibitors US Patent  US10092563 Publication Date 10/9/2018 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM288879
Synonyms:
US10092563, Compound 14
Type:
Small organic molecule
Emp. Form.:
C23H23ClN8O
Mol. Mass.:
462.935
SMILES:
Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)c1C#N |r|
Structure:
Search PDB for entries with ligand similarity: