Target
Cytochrome P450 family 11 subfamily B member 2
Ligand
BDBM191278
Substrate
n/a
Meas. Tech.
Aldosterone Synthase Inhibition Assay
pH
7.4±n/a
IC50
22.1±n/a nM
Comments
extracted
Citation
 Balestra, MBurke, JChen, ZCogan, DFader, LGuo, XMcKibben, BMarshall, DRNemoto, PAYu, H Aldosterone synthase inhibitors US Patent  US9181272 Publication Date 11/10/2015 
Target
Name:
Cytochrome P450 family 11 subfamily B member 2
Synonyms:
Aldosterone Synthase (CYP11B2)
Type:
n/a
Mol. Mass.:
51334.55
Organism:
Cercopithecus sabaeus
Description:
Aldeosterone synthase (CYP11B2) from frozen cynomolgus monkey adrenal gland
Residue:
451
Sequence:
MALRAKAEVCMAAPWLSLQRAQALSTRAARAPSTVLPFEAIPQRPGSRWLRLLQIWREQGYEHLHLEVHQTFQELGPIFRNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALRNKVVQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLSFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELALSRPQQYTGIVAELLLNAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQALRQESLAAAASISEHPQKATTELPLMRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNPALFPRPERYNPQRWLDIRGSGKNFHNVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN
  
Inhibitor
Name:
BDBM191278
Synonyms:
US9181272, 48
Type:
Small organic molecule
Emp. Form.:
C19H22N4O2
Mol. Mass.:
338.4036
SMILES:
NC(=O)N1CCCc2cc(cnc12)-c1cncc(c1)C1CCOCC1
Structure:
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